Protein/Protein Interactions in the Mammalian Heme Degradation Pathway
نویسندگان
چکیده
منابع مشابه
Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.
Heme oxygenase (HO) catalyzes the rate-limiting step in the O2-dependent degradation of heme to biliverdin, CO, and iron with electrons delivered from NADPH via cytochrome P450 reductase (CPR). Biliverdin reductase (BVR) then catalyzes conversion of biliverdin to bilirubin. We describe mutagenesis combined with kinetic, spectroscopic (fluorescence and NMR), surface plasmon resonance, cross-link...
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Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968-0519, USA Departamento de Parasitologia, Universidade de Sao Paulo, Sao Paulo, SP 05508-900, Brazil Departamento de Fisiologia e Farmacodinâmica, Instituto Os...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.582783